ASGE Adult and Pediatric Gastroenterology and Endoscopy Board Preparatory and Review Course

Fishman_Metabolic Liver

Pdf Summary

The document is a summary of a presentation on various topics related to the liver, including biliary atresia, genetic diseases of the liver, and liver mass differentiation. The presenter discusses the normal vascular anatomy of the liver and its various functions, such as dietary metabolism, bile creation, and toxin elimination. The difference between bile salts and bilirubin is explained, with bile salts being made of bile acids conjugated with glycine or taurine, while bilirubin is a breakdown product of red blood cells. The presentation also covers the hepatic zonal architecture and provides a genetics review.<br /><br />Biliary atresia is discussed, highlighting the importance of evaluating infants with jaundice after two weeks of age for cholestasis. The presentation emphasizes the need for timely evaluation and referral to a pediatric gastroenterologist or hepatologist if serum direct bilirubin levels are elevated. Other topics covered include liver diseases related to biliary transport conditions, such as bile acid synthesis defects and genetic diseases of biliary transport.<br /><br />The presenter also discusses various liver masses, including benign lesions like mesenchymal hamartoma, focal nodular hyperplasia, and hepatic adenoma, as well as malignant tumors like hepatoblastoma and hepatocellular carcinoma (HCC). The diagnostic process, treatment options, and therapeutic interventions for HCC are outlined.<br /><br />The summary concludes with a list of additional resources that may be beneficial for further research on the topics discussed. Overall, the presentation provides a comprehensive overview of liver-related conditions and their management.

Keywords

liver

biliary atresia

genetic diseases

liver mass differentiation

vascular anatomy

bile salts

bilirubin

cholestasis

hepatoblastoma

hepatocellular carcinoma