ASGE Adult and Pediatric Gastroenterology and Endoscopy Board Preparatory and Review Course | 2022-Review of Colorectal Cancer Screening, Polyposis/Non-polyposis Syndromes

Video Transcription

Video Summary

In this video, Jennifer Murat discusses several aspects of colorectal cancer, including screening, surveillance guidelines, and polyposis and nonpolyposis syndromes. She begins by discussing the trends in colorectal cancer, stating that it is the third most common cause of cancer and the second most common cause of cancer-related deaths in the United States. While the incidence and mortality rates for those over 50 have been declining due to screening, there has been a rise in early onset colorectal cancer. She then goes on to discuss the causes of colorectal cancer, including sporadic, familial, and hereditary syndromes. She explains the three main pathways of colorectal carcinogenesis: chromosomal instability, serrated pathway, and microsatellite instability pathway. Murat also mentions various risk factors associated with colorectal cancer, both non-modifiable and modifiable. She then moves on to the second objective, reviewing colorectal cancer screening and surveillance recommendations. She provides an example scenario and discusses when a patient should undergo a screening colonoscopy based on the current guidelines. Murat also highlights the post-polypectomy surveillance intervals for adenomas and serrated polyps. In the final objective, she discusses hereditary colorectal polyposis and non-polyposis syndromes, including Lynch syndrome, familial adenomatous polyposis, putzgecker syndrome, juvenile polyposis syndrome, and serrated polyposis syndrome. She mentions the criteria for testing and provides the recommended screening and surveillance guidelines for each syndrome. Murat concludes the video by answering two sample questions related to serrated polyps and family history of colon cancer. She also thanks the course directors and moderators and provides references for further information.

Asset Subtitle

Jennifer K. Maratt, MD, MS

Keywords

colorectal cancer

screening

surveillance guidelines

polyposis

nonpolyposis syndromes

carcinogenesis pathways