ASGE Annual GI Advanced Practice Provider Course (On-Demand) - Clinical Case-Based Learning (Day Two) | April 2023-Video 3 APP Video Tip of the week Primary Biliary Cholangitis

Video 3 APP Video Tip of the week Primary Biliary Cholangitis

Video Transcription

Video Summary

In this video, Joe Vacari discusses primary biliary cholangitis (PBC), a rare autoimmune disease that primarily affects women. The cause of PBC is unknown, but it is characterized by a T cell attack on the small bile duct epithelial cells. Fatigue and pruritus are common symptoms, and physical exam findings may include hyperpigmentation, xanthomas, xantholasmas, and hepatosplenomegaly. PBC should be considered in women in their fifth and sixth decade of life, and an elevated alkaline phosphatase with no evidence of biliary obstruction is a key diagnostic indicator. Treatment typically involves weight-based ursodeoxycholic acid, with combined therapy for non-responders. Pruritus management varies based on severity, and long-term monitoring is necessary. Complications of PBC include metabolic bone disease, hypercholesterolemia, fat malabsorption, and cirrhosis. The video promotes the ASGE annual advanced practice providers course happening on March 31st to April 1st.

Keywords

primary biliary cholangitis

autoimmune disease

T cell attack

symptoms

diagnostic indicator