ASGE Annual GI Advanced Practice Provider Course (On-Demand) - Clinical Case-Based Learning (Day Two)

Pdf Summary

This document presents two case studies focusing on liver disease. The first case study involves a 46-year-old male with abnormal transaminases, diabetes, family history of liver disease, and "tan" skin, likely indicating hereditary hemochromatosis. The second case involves a 70-year-old female with liver injury possibly caused by drug-induced liver disease from sulfamethoxazole/trimethoprim for a UTI. The text delves into the epidemiology, risk factors, clinical manifestations, and management of hereditary hemochromatosis and drug-induced liver disease (DILI), highlighting the importance of accurate diagnosis and appropriate treatment for good outcomes. It discusses the various classifications of DILI, associated drugs causing liver test abnormalities, histologic patterns, and factors influencing prognosis. The document emphasizes the significance of considering these conditions when faced with patients exhibiting liver abnormalities and underscores the importance of thorough evaluation, including detailed medical history, imaging, and liver biopsy when necessary. It also stresses the need for early recognition, withdrawal of offending drugs, and appropriate management tailored to the type and severity of liver disease. Ultimately, the document encourages healthcare providers to think critically, order the correct tests, and provide high-quality care to ensure positive patient outcomes in cases of liver disease.

Asset Subtitle

Joseph Vicari, MD, MBA, FASGE

Keywords

liver disease

case study

hereditary hemochromatosis

transaminases

diabetes

family history

drug-induced liver disease

sulfamethoxazole

trimethoprim

clinical manifestations