ASGE Annual GI Advanced Practice Provider Course (On-Demand) - Onboarding (Day One) | March 2023-Video 3 APP Video Tip of the week Primary Biliary Cholangitis

Video 3 APP Video Tip of the week Primary Biliary Cholangitis

Video Transcription

Video Summary

In this video, Joe Vacari discusses primary biliary cholangitis (PBC), a rare autoimmune disease primarily affecting women. The cause of PBC is unknown, and it is characterized by symptoms such as fatigue and pruritus. Physical exam findings may include hyperpigmentation of the skin, xanthomas, xantholasmas, and hepatosplenomegaly. PBC should be considered in female patients in their fifth and sixth decade of life with an elevated alkaline phosphatase and no evidence of biliary obstruction. The presence of certain criteria, such as elevated alkaline phosphatase, anti-mitochondrial antibodies, or histologic evidence, helps establish the diagnosis. Treatment typically involves ursodeoxycholic acid, and pruritus management depends on the severity of symptoms. Long-term monitoring is essential, including liver function tests and screening for complications such as metabolic bone disease and cirrhosis. The video concludes with a reminder about the ASGE annual advanced practice providers course.

Keywords

primary biliary cholangitis

autoimmune disease

women

symptoms

treatment