ASGE Annual GI Advanced Practice Provider Course (On-demand) (Day One) | March 2026-SESSION B: Hereditary Polyposis Syndromes

Video Transcription

Video Summary

The talk reviews hereditary polyposis syndromes and when to refer patients for genetic testing or a high-risk cancer clinic. The key referral trigger is polyp burden: more than 10–20 cumulative adenomas (often “10” as a practical threshold) should prompt evaluation for a polyposis syndrome. Updated post-polypectomy surveillance intervals are summarized: 10 years for normal exams, 7–10 years for 1–2 small adenomas, 3–5 years for multiple small adenomas, and 3 years for high-risk pathology (villous features, high-grade dysplasia, traditional serrated adenoma) or higher polyp counts. Major syndromes covered include FAP/attenuated FAP (APC; near-100% CRC risk in classic; extracolonic cancers), MUTYH-associated polyposis (autosomal recessive), Lynch syndrome (mismatch repair genes; Amsterdam criteria; extracolonic cancers), sessile serrated polyposis (WHO criteria; difficult-to-see lesions), and hamartomatous syndromes (Peutz-Jeghers, juvenile polyposis, PTEN-related). The speaker highlights the alarming rise in early-onset colorectal cancer and notes hereditary causes may account for up to 35%, emphasizing careful personal and family history and review of prior pathology.

Asset Subtitle

Vijaya Rao, MD, FASGE

Meta Tag

Concept Genetic Mutation Testing

Concept Lynch Syndrome

Concept Hereditary Polyposis

Concept Post-Polypectomy Surveillance

Concept Familial Adenomatous Polyposis

Concept MUTYH-Associated Polyposis

Concept Sessile Serrated Polyposis Syndrome

Concept Peutz-Jeghers Syndrome

Concept Juvenile Polyposis

Concept PTEN Hamartoma Syndrome

Keywords

hereditary polyposis syndromes

genetic testing referral criteria

adenoma polyp burden threshold

post-polypectomy surveillance intervals

Lynch syndrome mismatch repair genes

familial adenomatous polyposis APC MUTYH

Genetic Mutation Testing

Lynch Syndrome

Hereditary Polyposis

Post-Polypectomy Surveillance

Familial Adenomatous Polyposis

MUTYH-Associated Polyposis

Sessile Serrated Polyposis Syndrome

Peutz-Jeghers Syndrome

Juvenile Polyposis

PTEN Hamartoma Syndrome