ASGE Annual GI Advanced Practice Provider Course (Virtual) - Clinical Case-Based Learning (Day Two) | April 2023-Video 3 APP Video Tip of the week Primary Biliary Cholangitis

Video 3 APP Video Tip of the week Primary Biliary Cholangitis

Video Transcription

Video Summary

In this video, Joe Vacari provides an overview of primary biliary cholangitis (PBC). PBC is a rare autoimmune disease that predominantly affects women. The exact cause is unknown, but it is believed to involve T cell attack on bile duct cells. Common symptoms include fatigue and varying degrees of pruritus. Physical exams may reveal skin pigmentation, xanthomas, and hepatosplenomegaly. PBC is diagnosed by elevated alkaline phosphatase levels, presence of anti-mitochondrial antibodies, or histologic evidence. Treatment typically involves weight-based ursodeoxycholic acid, with obeticholic acid as an option for non-responders. Pruritus management varies based on severity. Long-term monitoring is necessary to assess liver function and screen for complications such as bone disease and cirrhosis.

Keywords

primary biliary cholangitis

autoimmune disease

T cell attack

fatigue

pruritus