ASGE Annual GI Advanced Practice Provider Course (Virtual) - Onboarding (Day One) | March 2023-Video 3 APP Video Tip of the week Primary Biliary Cholangitis

Video 3 APP Video Tip of the week Primary Biliary Cholangitis

Video Transcription

Video Summary

In this video, Joe Vacari discusses primary biliary cholangitis (PBC), which is a rare autoimmune disease affecting mostly women. The cause of PBC is unknown but possible factors include environmental causes, toxins, medications, and infections. PBC is a progressive disease with symptoms such as fatigue and varying levels of pruritus. Physical examination may reveal hyperpigmentation of the skin and hepatosplenomegaly. Diagnosing PBC involves ruling out biliary obstruction and meeting certain criteria such as elevated alkaline phosphatase, presence of anti-mitochondrial antibodies (AMA), or histologic evidence. Liver biopsy is not necessary for diagnosis. Treatment typically involves ursodeoxycholic acid (UDCA), and combined therapy with obeticholic acid (OBA) may be used if patients don't respond to UDCA. Pruritus can be managed with various measures depending on severity. Long-term monitoring is important, and complications of PBC include metabolic bone disease, hypercholesterolemia, fat malabsorption, and cirrhosis. The video concludes by promoting the GI advanced practice providers course. No credits are mentioned.

Keywords

primary biliary cholangitis

autoimmune disease

environmental causes

symptoms

diagnosis