ASGE Annual Postgraduate Course: Clinical Challenges and Real-Time Decision Making in GI Endoscopy (Live and Virtual) | May 2023-Mechanisms of Action for Endoscopic Therapies: How Do They Work? Does it Matter?

Mechanisms of Action for Endoscopic Therapies: How Do They Work? Does it Matter?

Video Transcription

Video Summary

In this video, Dr. Pichamon-Quiropinho from Brigham Women's Hospital and Harvard Medical School discusses the mechanisms of action for different endoscopic therapies used for weight loss and improvement of metabolic comorbidities. The talk begins with an overview of endoscopic bariatric and metabolic therapies (EBMTs) and their different subtypes, such as gastric balloons, transpyloric shuttle, endoscopic sleeve, aspiration therapy, duodenal jejunal bypass liner, and duodenal mucosal resurfacing. The speaker highlights that gastric interventions primarily work by influencing gastric emptying and gut hormones, while small bowel interventions work by affecting incretin hormones and other factors. The talk also touches upon the association between EBMTs and ghrelin, GLP-1, PYY, and other gut hormones. The speaker presents data from various studies, including randomized controlled trials, to support the effectiveness of these therapies. Overall, the video underscores the need for more mechanistic studies to better understand and personalize endoscopic therapies for patients with obesity and metabolic conditions.

Asset Subtitle

Pichamol Jirapinyo, MD, MPH

Keywords

endoscopic therapies

weight loss

metabolic comorbidities

gastric interventions

small bowel interventions

gut hormones