ASGE DDW Videos from Around the World | 2024-ELECTROPORATION FOR TREATMENT OF COLORECTAL CANCER IN AN ONCOPIG MODEL

ELECTROPORATION FOR TREATMENT OF COLORECTAL CANCER IN AN ONCOPIG MODEL

Video Transcription

Video Summary

Irreversible electroporation therapy is being explored as an alternative treatment for colorectal cancer to provide local symptom control without surgery. This non-thermal ablative therapy uses electrical pulses to increase cell membrane permeability and induce cell apoptosis. In a porcine model, the therapy was delivered endoscopically with promising results, including effective hemostasis and tumor ablation. The procedure was well tolerated with no adverse outcomes observed. Electroporation could be a potential option for palliative and adjunct therapy in colorectal cancer, offering hope for improved outcomes in non-surgical candidates.

Asset Subtitle

Manus Rugivarodom

Keywords

Irreversible electroporation therapy

colorectal cancer

non-thermal ablative therapy

electrical pulses

cell apoptosis