ASGE DDW Videos from Around the World | 2025-PROXIMAL INTESTINAL MUCOSAL ABLATION (PIMA) FOR THE TREATMENT OF TYPE 2 DIABETES

PROXIMAL INTESTINAL MUCOSAL ABLATION (PIMA) FOR THE TREATMENT OF TYPE 2 DIABETES

Video Transcription

Video Summary

The PEMA (Proximal Intestinal Mucosal Ablation) procedure is a novel method for treating type 2 diabetes. It mimics the effects of gastric bypass by using radiofrequency energy to ablate up to 75cm of duodenal mucosa. This aims to improve blood glucose levels without significant weight loss. A study on a 56-year-old woman showed that the procedure is safe and reduced HbA1c from 10% to 8.2%, with no serious adverse events. The extended ablation length potentially offers more substantial and lasting glycemic improvements, and further research is ongoing.

Asset Subtitle

Benjamin Norton

Keywords

Proximal Intestinal Mucosal Ablation

type 2 diabetes

radiofrequency energy

glycemic improvements

duodenal mucosa