ASGE DDW Videos from Around the World | 2026-REGROWING THE HUMAN ESOPHAGUS IN VIVO WITH ENDOSCOPIC BIOENGINEERING

REGROWING THE HUMAN ESOPHAGUS IN VIVO WITH ENDOSCOPIC BIOENGINEERING

Video Transcription

Video Summary

A 27-year-old man with a gunshot-related upper esophageal destruction was treated endoscopically using a stent-based tissue engineering approach. A covered stent was placed across a 5 cm defect to promote granulation tissue growth in the mediastinal cavity, then removed after 3 months. The granulation tissue was sprayed with autologous platelet-rich plasma and covered with a human placental membrane held in place by a temporary stent. Three months later, endoscopy, ultrasound, biopsies, and manometry showed a reconstructed, functional neoesophagus with normal squamous epithelium and intact wall layers. The patient resumed a normal diet and remained asymptomatic.

Asset Subtitle

Video Plenary I
Submitted by Talia Malik

Keywords

esophageal reconstruction

gunshot injury

stent-based tissue engineering

platelet-rich plasma

human placental membrane