ASGE Esophagology: Tailoring Management from Testing to Treatment (Live and Virtual) | July 2022-Update on Eosinophilic Esophagitis

Video Transcription

Video Summary

In this video, Dr. Iko Hirano, a professor of medicine at Northwestern University School of Medicine, provides an update on eosinophilic esophagitis (EOE) and discusses four misconceptions in its management. He emphasizes that symptoms are not a reliable indicator of disease activity and can often be misleading. Maintenance therapy is necessary for most patients, as untreated or unrecognized EOE can lead to esophageal strictures. Dr. Hirano also points out that endoscopy is limited in accurately detecting strictures, and additional testing such as barium esophagram or dilation may be needed. Lastly, he highlights the unmet need for treatment options, as current therapies like swallowed topical corticosteroids have response rates of around 65% and many patients do not respond. He discusses the potential efficacy of monoclonal antibodies, such as syndacomab and dupilumab, which have shown positive results in clinical trials and recently received FDA approval for the treatment of EOE.

Asset Subtitle

Ikuo Hirano

Keywords

eosinophilic esophagitis

misconceptions in management

maintenance therapy

esophageal strictures

monoclonal antibodies

FDA approval