ASGE Interventional IBD: Management of Complications | March 2022-Molecular Imaging: Guiding Medical & Endoscopic Therapy of IBD

Video Transcription

Video Summary

In the video, Dr. Timo Rath discusses the use of molecular imaging in guiding medical and endoscopic therapy in inflammatory bowel disease (IBD). Molecular imaging involves labeling cellular or subcellular structures with fluorescent dyes and visualizing them with endoscopic devices. An ideal molecular probe should have high affinity for the target, low background signals, rapid binding kinetics, fast clearance, deep tissue penetration, and minimal immunogenicity. Peptides and antibodies are commonly used molecular probes, with peptides offering advantages such as small size and good tissue penetration. Dr. Rath discusses studies showing the use of molecular imaging to predict therapeutic response in IBD patients. He also highlights the development of novel molecular probes, such as gamma-glutamyl hydroxymethyl rhodamine green, which can specifically visualize cancer cells. Additionally, he mentions the use of multi-photon microscopy for label-free molecular imaging. The potential future developments include advancing molecular imaging techniques and enabling precise detection of colorectal and colitis-associated cancer.

Asset Subtitle

Timo Rath, MD

Keywords

molecular imaging

inflammatory bowel disease

endoscopic therapy

molecular probes

therapeutic response