ASGE Interventional IBD: Management of Complications (On-Demand)| March 2022-Molecular Imaging: Guiding Medical & Endoscopic Therapy of IBD

Molecular Imaging: Guiding Medical & Endoscopic Therapy of IBD

Video Transcription

Video Summary

In this video, Dr. Timo Rath, a leading expert in molecular imaging in inflammatory bowel disease (IBD) from University Elegon in Germany, discusses the use of molecular imaging in guiding medical and endoscopic therapy for IBD. He explains that molecular imaging involves labeling cellular structures with fluorescent dyes and visualizing them using endoscopic techniques. Dr. Rath discusses the ideal characteristics of a molecular probe, including high affinity for the target, rapid binding kinetics, and deep tissue penetration. He mentions that peptides and antibodies are commonly used molecular probes. Dr. Rath also discusses the use of molecular imaging to predict therapeutic response in IBD patients, citing a landmark study that found increased apoptotic cells in patients who responded to anti-TNF therapy. He also explains the use of molecular probes to identify tumor cells in colorectal cancer and colitis-associated cancer. Dr. Rath concludes by discussing the future potential of molecular imaging, including the development of label-free techniques using multi-photon microscopy.

Asset Subtitle

Timo Rath, MD

Keywords

molecular imaging

inflammatory bowel disease

medical therapy

endoscopic therapy

molecular probe