ASGE Masterclass: Barrett’s Esophagus, GERD and Esophageal Adenocarcinoma (On Demand) | February 2022-Screening and Surveillance in Barrett's Esophagus: Getting to the Next Level

Video Transcription

Video Summary

In this video, Dr. Iyer discusses screening and surveillance in Barrett's esophagus. He begins by explaining the importance of screening and surveillance for patients at risk of developing Barrett's esophagus and the progression to esophageal adenocarcinoma. The incidence of esophageal adenocarcinoma has increased over the last few decades, and the mortality associated with it has also increased. Dr. Iyer highlights the need to detect Barrett's and dysplasia or early cancer through screening and surveillance in order to prevent progression to esophageal adenocarcinoma.<br /><br />He discusses various technologies that are being developed to improve screening and detection in Barrett's esophagus. These include non-endoscopic esophageal sampling devices combined with biomarkers, such as the cytosponge and the isocheck balloon, as well as exhaled volatile organic compounds. He presents studies that have shown promising results in terms of accuracy, safety, and ease of use for these technologies.<br /><br />Dr. Iyer also talks about the WATS (Wide Area Transepithelial Sampling) brush-based technology for dysplasia detection. This technology allows for better sampling of the Barrett's mucosa and has been shown to increase the yield of dysplasia compared to standard biopsies.<br /><br />Lastly, he discusses the importance of predicting progression in Barrett's esophagus and mentions the tissue cipher assay, which combines biomarkers and morphology to provide a risk score for progression. He presents the results of a pooled analysis study that evaluated the performance of the tissue cipher assay in predicting progression.<br /><br />In conclusion, Dr. Iyer highlights the progress being made in minimally invasive tools for Barrett's detection, the potential of WATS for dysplasia detection, and the development of risk stratification tools. These advancements have the potential to improve early detection and management of Barrett's esophagus, ultimately reducing the risk of esophageal adenocarcinoma.

Keywords

screening

surveillance

Barrett's esophagus

esophageal adenocarcinoma

technologies

dysplasia detection

risk stratification