ASGE Masterclass: Barrett’s Esophagus, GERD and Esophageal Adenocarcinoma (On Demand) | February 2022-The Best and Worst of PPIs: Pearls in medical management of GERD

Video Transcription

Video Summary

The video is a talk on the topic of proton pump inhibitors (PPIs) and their role in the medical management of gastroesophageal reflux disease (GERD). The speaker discusses the prevalence of GERD in the United States and the significant costs associated with the condition. PPIs are commonly prescribed for GERD, and their usage has increased over time, although the overall proportion of PPI users has only slightly increased. The speaker explains that PPIs work by blocking the terminal step of acid secretion, and to be effective, they need to be taken regularly. PPIs have various pharmacokinetic and pharmacodynamic differences, and different PPIs have shown varying effectiveness in healing esophagitis. The speaker highlights that PPIs may have certain adverse effects, but available evidence is limited and inconclusive. The speaker also discusses other medical interventions for GERD, such as lifestyle modifications, prokinetics, and H2 receptor blockers. Newer drugs like potassium acid channel blockers show promise but are not yet available in the US. The speaker concludes that PPIs are generally safe and effective, and in cases where they are not effective, further evaluation and alternative treatments may be considered.

Keywords

PPIs

GERD

acid secretion

esophagitis

adverse effects

alternative treatments