ASGE Recognized Industry Associate (ARIA) Training Program for Regeneron | June 2022-June28 Session 10

Video Transcription

Video Summary

The video discussed the pathophysiology, epidemiology, and definition of eosinophilic esophagitis (EOE). EOE is defined as a chronic immune-mediated food antigen-driven disease that requires both clinical symptoms and histology for diagnosis. Clinical symptoms typically include dysphagia and swallowing difficulties, while histology requires esophageal biopsies showing inflammation with at least 15 eosinophils per high-power field. The video also discussed the history of EOE, noting that it was first reported in the late 1970s and initially thought to be related to reflux disease. However, subsequent studies suggested a potential link to allergic conditions and food allergies. Consensus guidelines for diagnosis and management of EOE were first published in 2007 and have been updated periodically since then. The video emphasized the importance of early diagnosis and treatment to prevent fibrosis and strictures in the esophagus. The natural history of EOE involves progression from inflammation to fibrosis, with longer diagnostic delay associated with an increased risk of developing strictures and fibrotic features. The video also mentioned that certain risk factors, such as exposure to antibiotics at a young age, mode of delivery, and family history, may be associated with the development of EOE. Finally, the video highlighted the prevalence of EOE, which is estimated to be around 34 per 100,000 patients. However, the prevalence may be increasing due to improved awareness and diagnosis of the condition.

Asset Subtitle

Walter Chan, MD, MPH

Keywords

eosinophilic esophagitis

chronic immune-mediated disease

clinical symptoms

histology

fibrosis

diagnosis

prevalence