ASGE Recognized Industry Associate (ARIA) Training Program for Regeneron and Sanofi | August 2024-Epidemiology and Diagnosis of EoE

Epidemiology and Diagnosis of EoE

Pdf Summary

Eosinophilic Esophagitis (EoE) is a chronic immune-mediated disease primarily driven by food antigens, where inflammation in the esophagus is characterized by eosinophils. The diagnosis requires the presence of 15 or more eosinophils per high-power field in biopsy specimens. EoE is believed to have historical roots dating back to the late 20th century and has been linked to food allergies. The condition is more common in males, typically presenting in the 3rd or 4th decade of life, with symptoms like dysphagia and food impaction. The prevalence of EoE varies globally, with a significant number of patients having a history of atopic diseases. Family history and certain environmental factors can contribute to EoE development, leading to a diverse range of symptoms across different age groups. Endoscopic findings include specific patterns like rings, exudates, and furrows. The natural history of EoE highlights the significance of early diagnosis and treatment to prevent the progression to fibrotic complications such as strictures. In conclusion, EoE is an inflammatory condition that can lead to fibrosis over time, emphasizing the importance of timely intervention to manage its progression effectively.

Keywords

Eosinophilic Esophagitis

chronic disease

immune-mediated

food antigens

eosinophils

dysphagia

food allergies

atopic diseases

endoscopic findings

fibrosis