ASGE Recognized Industry Associate (ARIA) Training Program for Regeneron and Sanofi | August 2024-Epidemiology and Diagnosis of EoE

Video Transcription

Video Summary

The video transcript covers an in-depth presentation on eosinophilic esophagitis (EOE), a chronic immune-mediated disease driven by food antigens. The speaker, Dr. Gonzalez, outlines the definition and history of EOE, emphasizing its evolution from being misdiagnosed as GERD to its recognition as a distinct condition in the 1990s. Clinical diagnosis requires both symptomatic assessment and pathologic confirmation through biopsies showing eosinophil-predominant inflammation.<br /><br />The epidemiology of EOE shows it as a relatively rare but increasing condition, associated with high atopy rates among patients. Specific risk factors include early life antibiotic use, C-sections, and NICU admissions, among others. Family history also points to a genetic predisposition, with notable higher incidence among twins.<br /><br />Clinical symptoms vary by age, with adults presenting predominantly with dysphagia and food impactions, while children may show vomiting and feeding issues. The presentation is coupled with distinct endoscopic and histologic features, including rings, furrows, edema, and strictures.<br /><br />Treatment involves maintenance therapies, primarily to prevent progression to fibrosis, and periodic endoscopies to monitor disease state. Closing, Dr. Gonzalez discusses variability in patient responses and the importance of individualized treatment plans, indicative of ongoing research into the disease’s different phenotypes and genetic markers.

Asset Subtitle

Nirmala Gonsalves, MD

Keywords

eosinophilic esophagitis

EOE

immune-mediated disease

dysphagia

endoscopy

genetic predisposition

fibrosis prevention

individualized treatment