ASGE Recognized Industry Associate (ARIA) Training Program for Regeneron and Sanofi | August 2024-Pathologists Perspective of EoE

Pathologists Perspective of EoE

Pdf Summary

This document provides insights into eosinophilic esophagitis (EoE) from a pathologist's perspective. The curriculum emphasizes differential diagnoses, histologic criteria, and clinical findings for diagnosing EoE. Key points include the definition of EoE as a chronic immune-mediated esophageal disease with eosinophil predominant inflammation. The incidence, prevalence, associated risk factors, and diagnostic criteria for EoE are discussed.<br /><br />The document highlights the challenges in diagnosing EoE, such as limited correlation with symptoms, variability in quantification methods, and incomplete assessment of disease activity. Additionally, it compares EoE to reflux esophagitis, noting similarities and differences in clinical presentation, histological features, and diagnostic approaches.<br /><br />Pathologists play a crucial role in diagnosing EoE by assessing eosinophil density in esophageal tissue samples. Diagnostic tips include considering all features collectively, obtaining endoscopic findings and clinical history, and ensuring an adequate number of biopsies for accurate diagnosis.<br /><br />In conclusion, understanding the pathological features and diagnostic challenges of EoE is essential for accurate diagnosis and management. This document serves as an internal educational resource for healthcare professionals involved in the evaluation and treatment of patients with EoE.

Keywords

eosinophilic esophagitis

EoE

pathologist perspective

differential diagnoses

histologic criteria

clinical findings

diagnostic challenges

eosinophil density

reflux esophagitis

biopsies