Colonoscopy - Discussion on the Nordic-European Initiative Trial Report Findings | October 2022-Colonoscopy Discussion on the Nordic-European Initiative Trial Report

Video Transcription

Video Summary

In this webinar, sponsored by the American Society for Gastrointestinal Endoscopy, experts discuss the findings of a study on the effect of colonoscopy screening on risks of colorectal cancer and related death. The study, conducted by the Nordic European Initiative on Colorectal Cancer, involved nearly 100,000 participants aged 55 to 64 who were randomly assigned to either colonoscopy screening or usual care. The study found an 18% reduction in the relative risk of colorectal cancer for those invited to screening. The overall risk of colorectal cancer at 10 years was 1% in the screening group. It was also found that those who attended the screening had a 31% reduction in colorectal cancer incidence. The study did not find a reduction in colorectal cancer mortality for the intention-to-treat analysis, but the per-protocol analysis suggested a reduction of up to 50%. The experts discussed the implications of the study and the differences in colonoscopy practice between countries. They emphasized the importance of focusing on the per-protocol analysis and the need for further research to compare the results of the study with other screening methods, such as flexible sigmoidoscopy. This summary is based on the transcript of a video webinar sponsored by the American Society for Gastrointestinal Endoscopy and features the primary author, Professor Michael Brethauer, and other experts in the field.

Asset Subtitle

On October 9, The New England Journal of Medicine (NEJM) released a Nordic-European Initiative on Colorectal Cancer (NordICC) trial report that may be interpreted to cast doubt on the effectiveness of colonoscopy as a screening test to detect colorectal cancer, its effect on the risks of colorectal cancer and related deaths. Hear directly from ASGE President Bret Petersen, MD, MASGE, ASGE Past-President Douglas Rex, MD, MASGE, and Jason Dominitz, MD, MHS, FASGE as well as the authors of the report, Michael Bretthauer, MD, PhD and Michal Kaminiski MD PhD, for an engaging discussion on the findings.

Keywords

webinar

American Society for Gastrointestinal Endoscopy

study

colonoscopy screening

colorectal cancer

death

Nordic European Initiative on Colorectal Cancer

participants

random assignment