EoE Module 1 References-Hahn et al Clin Gastroenterol Hepatol 2023 Global Incidence and Prevalence of EoE 1976-2022 A Systematic Review and Meta-analysis

Hahn et al Clin Gastroenterol Hepatol 2023 Global Incidence and Prevalence of EoE 1976-2022 A Systematic Review and Meta-analysis

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This systematic review and meta-analysis, conducted by Hahn et al., assessed the global incidence and prevalence of Eosinophilic Esophagitis (EoE) from 1976 to 2022. The study compiled data from 40 studies encompassing over 288 million participants and 147,668 EoE patients from 15 countries. The global incidence of EoE was calculated at approximately 5.31 cases per 100,000 inhabitant-years, while the global prevalence was found to be 40.04 cases per 100,000 inhabitant-years.<br /><br />Key findings include significant regional variations, with higher incidence and prevalence rates in high-income countries (HICs) compared to low- or middle-income countries (LMICs). Males had a higher incidence and prevalence of EoE than females, and North America showed higher rates compared to Europe and Asia. Notably, the incidence and prevalence have surged over the decades, marking a substantial rise from 1976 to 2022.<br /><br />The review attributed the increase in EoE cases partly to evolving diagnostic criteria, improved disease awareness, and better diagnostic technologies like endoscopy. Key factors influencing EoE's rise include early-life environmental exposures and the associated rise in allergic and atopic diseases. However, the exact reasons for geographic variability remain unclear, potentially involving differences in healthcare accessibility, dietary habits, and environmental exposures.<br /><br />Additionally, the analysis revealed significant heterogeneity among the studies, attributed to varied diagnostic criteria, healthcare practices, and regional disparities. There was a call for increased awareness and standardized diagnostic methods for EoE, particularly in underrepresented regions like Asia, South America, and Africa.<br /><br />In conclusion, the study highlights the substantial and growing global burden of EoE, emphasizing the need for more comprehensive research and global awareness to manage and mitigate the impact of this disease.

Keywords

Eosinophilic Esophagitis

global incidence

global prevalence

meta-analysis

regional variations

diagnostic criteria

environmental exposures

healthcare accessibility

allergic diseases

standardized diagnostic methods