EoE Module 1 References-Jensen et al JACI 2018 Prenatal intrapartum and postnatal factors are associated with pediatric EoE

Jensen et al JACI 2018 Prenatal intrapartum and postnatal factors are associated with pediatric EoE

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A recent study by Elizabeth T. Jensen and colleagues examined the association between prenatal, intrapartum, and postnatal factors and the risk of developing pediatric eosinophilic esophagitis (EoE). Data was collected through a case-control study at Cincinnati Children’s Hospital Medical Center (CCHMC) involving 127 EoE cases and 121 control subjects. The study found significant associations between certain early-life factors and the risk of EoE.<br /><br />Key Results:<br />- <strong>Prenatal Factors</strong>: Maternal fever during pregnancy and preterm labor were significantly associated with increased risks of EoE. Specifically, maternal fever had an adjusted odds ratio (aOR) of 3.18, while preterm labor had an aOR of 2.18.<br />- <strong>Intrapartum Factors</strong>: Cesarean delivery was linked to a 77% increased risk of EoE with an aOR of 1.77.<br />- <strong>Postnatal Factors</strong>: Use of antibiotics (aOR 2.30) and acid suppressant therapy (aOR 6.05) during infancy were also significantly associated with increased EoE risk. Interestingly, having a furry pet in the home during the postnatal period was found to be protective against EoE (aOR 0.58).<br />- <strong>Other Factors</strong>: No significant associations were found for breastfeeding, maternal smoking, or maternal use of prenatal vitamins or folic acid supplements.<br /><br />The study noted that these factors are potentially modifiable, suggesting implications for prevention and early interventions. Results indicate that children exposed to these risk factors may benefit from modified evaluations and healthcare strategies to mitigate the risk of developing EoE. Further research into gene-environment interactions is recommended to enhance predictive accuracy and develop targeted prevention approaches. <br /><br />Overall, this study highlights the importance of early-life exposures in the pathogenesis of pediatric EoE and underscores the complexity of environmental and genetic factors in influencing disease outcomes.

Keywords

pediatric eosinophilic esophagitis

prenatal factors

intrapartum factors

postnatal factors

case-control study

Cincinnati Children’s Hospital

maternal fever

preterm labor

Cesarean delivery

antibiotics