EoE Module 1 References-Limketkai et al Gut 2019 ABSTRACT Epidemiology and implications of concurrent diagnosis of EoE and IBD

Limketkai et al Gut 2019 ABSTRACT Epidemiology and implications of concurrent diagnosis of EoE and IBD

Pdf Summary

The study "Epidemiology and implications of concurrent diagnosis of eosinophilic oesophagitis (EoO) and IBD based on a prospective population-based analysis" by Berkeley N Limketkai et al., published in December 2019 in "Gut" journal, investigates the connection between EoO and inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC). Utilizing data from the Truven MarketScan database (2009-2016), the study estimates the incidence and prevalence of EoO in patients with CD or UC, and vice versa, employing Cox proportional hazards and Kaplan-Meier methods to assess the risk of related complications.<br /><br />Key findings include:<br />- Among the studied population of 134,013,536 individuals, the incidence rates were 23.1 for EoO, 51.2 for CD, and 55.2 for UC per 100,000 person-years.<br />- Patients with CD or UC have a significantly higher risk of developing EoO, with incidence rate ratios (IRR) of 5.4 and 3.5 respectively, and prevalence ratios (PR) of 7.8 and 5.0.<br />- Conversely, patients with EoO are at a higher risk of developing IBD, with IRRs of 5.7 for CD and 3.4 for UC, and PRs of 7.6 for CD and 4.9 for UC.<br />- The concurrent diagnosis of EoO and IBD increases the risk of IBD-related complications (adjusted hazard ratios of 1.09 for CD and 1.10 for UC) but decreases the risk of EoO-related complications (adjusted hazard ratio of 0.59).<br /><br />The study concludes that there is a significant reciprocal risk between EoO and IBD and that having both conditions might alter complication risks. Further research is recommended to understand the underlying pathogenic mechanisms.

Keywords

Eosinophilic Oesophagitis

Inflammatory Bowel Disease

Crohn's Disease

Ulcerative Colitis

Epidemiology

Incidence Rates

Prevalence Ratios

Cox Proportional Hazards

Kaplan-Meier Methods

Truven MarketScan Database