EoE Module 13 References-DoucetLadeveze et al Front Pediatr 2019 Transciptomic analysis links EoE and atopic dermatitis

DoucetLadeveze et al Front Pediatr 2019 Transciptomic analysis links EoE and atopic dermatitis

Pdf Summary

The study investigates the molecular linkages between eosinophilic esophagitis (EoE), atopic dermatitis (AD), and allergic airway (AA) diseases, focusing on interleukin 13 (IL-13) involvement in gene expression. EoE, which often co-occurs with other atopic disorders like AD and AA, shares similarities in inflammation and immune response across these diseases. This research aimed to analyze the overlap in mRNA expression profiles among the three conditions and highlight the role of IL-13 in modulating gene expression.<br /><br />The study used transcriptomic analysis on human tissues and cell cultures stimulated with IL-13 to identify common dysregulated genes across these diseases. It found a greater overlap between EoE and AD transcriptomes than between EoE and AA, especially highlighting shared immune and inflammatory components. Key genes involved include filaggrin, histamine receptor H1, and claudin 1, which are part of the inflammatory and immune response pathways in these disorders.<br /><br />IL-13-stimulated cell models revealed a stronger transcriptomic match with EoE than with AD or AA, suggesting a more significant role of IL-13 in EoE pathogenesis. This implicates epithelial responses especially in the esophagus and skin, offering insights into potential shared therapeutic strategies targeting IL-13 pathways.<br /><br />The study concludes that EoE shares a considerable molecular framework with AD rather than AA, suggesting possibilities for common treatments for these Th2-associated diseases. Despite the overlap, unique gene regulation patterns suggest disease-specific pathways that require targeted interventions. These findings provide a rationale for developing therapies that address these shared and distinct molecular pathways in allergic diseases. The research highlights the importance of IL-13 in shaping the gene expression landscape of these conditions, supporting its potential as a therapeutic target.

Keywords

eosinophilic esophagitis

atopic dermatitis

allergic airway diseases

interleukin 13

gene expression

transcriptomic analysis

inflammation

immune response

IL-13 pathways

therapeutic strategies