EoE Module 13 References-Vernon et al Allergy Asthma Proc 2014 Comparison of atopic features between children and adults with EoE

Vernon et al Allergy Asthma Proc 2014 Comparison of atopic features between children and adults with EoE

Pdf Summary

The study by Vernon et al. explores differences in atopic features between children and adults with eosinophilic esophagitis (EoE), a chronic inflammatory condition associated with atopic disorders such as asthma, allergic rhinitis, and food allergies. EoE presents variably in children and adults, and the investigation aimed to determine if there were differences in atopic sensitization based on age.<br /><br />The research involved a retrospective review of 100 patients (50 children and 50 adults) diagnosed with EoE, examining their demographic and clinical data, atopic history, and results from allergy testing (skin-prick tests, serum IgE, and atopy patch testing).<br /><br />Key findings include:<br />- A higher percentage of children had asthma (52%) compared to adults (24%), which was statistically significant.<br />- There was no significant difference between children and adults regarding histories of allergic rhinitis, atopic dermatitis, or IgE-mediated food allergies.<br />- Both groups had similar rates of immediate-type sensitization to foods and aeroallergens.<br />- More children had positive reactions to foods on atopy patch testing compared to adults (62% vs. 31%), also statistically significant.<br /><br />The study suggests that while both children and adults with EoE experience high rates of atopic conditions, children are more likely to have asthma and positive patch test results to foods. The research highlights the importance of recognizing and understanding atopic conditions in the management of EoE across different age groups. These findings contribute to the broader understanding of EoE and its association with atopic diseases, indicating that while IgE-mediated food allergies are equally prevalent across ages, non-IgE-mediated responses might be more significant in children.

Keywords

eosinophilic esophagitis

atopic features

children vs adults

asthma

allergic rhinitis

food allergies

atopy patch testing

IgE-mediated allergies

age-related differences

atopic sensitization