EoE Module 8 References-Kliewer et al Gastroenterology 2019 DDW abstract 535 Efficacy of 1Fed vs 6FED for treatment of EoE in adults Results of RC SOFEED trial

Kliewer et al Gastroenterology 2019 DDW abstract 535 Efficacy of 1Fed vs 6FED for treatment of EoE in adults Results of RC SOFEED trial

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The document consists of abstracts from the American Gastroenterological Association's conference, focusing primarily on the inflammatory and cancer-promoting processes in gastric conditions and the efficacy of dietary treatments for eosinophilic esophagitis (EoE).<br /><br />1. **Helicobacter pylori and Gastric Cancer (Abstract 533):** This study analyzes the role of the TFF1 gene in suppressing inflammation-related factors in gastric cancer, particularly focusing on NFκB and STAT3 activation pathways initiated by H. pylori infection. TFF1 appears to act as a tumor suppressor by blocking complex formations between interleukin receptors and GP130, reducing inflammatory gene expression and inhibiting NFκB-STAT3 activation, ultimately demonstrating its anti-inflammatory and tumor-suppressive functions.<br /><br />2. **Immune Responses in Gastritis (Abstract 534):** The researchers compare Helicobacter pylori-induced gastritis and autoimmune gastritis, finding similar immune cell infiltrations and cytokine profiles between the two, suggesting that regardless of trigger, these conditions lead to similar inflammatory and metaplastic changes. Their findings propose that focusing on the common pathways may enhance understanding and treatment of inflammation-triggered gastric cancer.<br /><br />3. **Dietary Treatments for Eosinophilic Esophagitis (Abstract 535):** Comparing one-food elimination (animal milk) with six-food elimination diets, the trial found no significant difference in effectiveness between the two approaches in adults with EoE, though the six-food variant was more beneficial for some non-responders to one-food elimination and for those who subsequently tried steroid treatment.<br /><br />4. **Aging and Eosinophilic Esophagitis (Abstract 536):** The study highlights how age-related decline in cell autophagy might contribute to increased fibrosis in EoE, proposing that rejuvenating autophagy pathways could minimize fibrosis and esophageal tissue remodeling.<br /><br />5. **Identifying Eosinophilic Gastritis and Duodenitis (Abstract 537):** By systematically screening patients with chronic gastrointestinal symptoms, the study identifies a substantial number of patients with histological criteria for eosinophilic gastritis or duodenitis, previously undiagnosed, suggesting that intentional biopsies could reveal underrecognized conditions, leading to more targeted treatments.<br /><br />These abstracts underline significant advancements in understanding gastric conditions and improving treatments, illuminating similar underlying mechanisms in ostensibly different disorders.

Keywords

Helicobacter pylori

gastric cancer

TFF1 gene

inflammation

eosinophilic esophagitis

dietary treatments

immune responses

gastritis

autophagy

eosinophilic gastritis