EoE ToT Module 2 References-Dellon et al Clin Gastroenterol Hepatol 2022 International consensus recommendations for EGID nomenclature

Dellon et al Clin Gastroenterol Hepatol 2022 International consensus recommendations for EGID nomenclature

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The document details the creation of an international consensus on eosinophilic gastrointestinal disease (EGID) nomenclature. Eosinophilic diseases of the gastrointestinal (GI) tract, characterized by GI symptoms and eosinophilic inflammation, lacked standardized terminology, causing confusion in clinical and research settings. A group of 91 experts used the Delphi methodology to establish a unified nomenclature. The process involved iterative discussions and surveys over several rounds, achieving a significant consensus.<br /><br />**Key Outcomes:**<br />1. **Umbrella Term:** "Eosinophilic gastrointestinal disease (EGID)" will be used as the overarching term for these conditions.<br />2. **Specific Naming:** Locations in the GI tract with eosinophilic inflammation will be specifically named:<br />   - **EoG**: Eosinophilic Gastritis for stomach involvement.<br />   - **EoN**: Eosinophilic Enteritis for small intestine involvement.<br />   - **EoC**: Eosinophilic Colitis for colon involvement.<br />   - **EoE**: Eosinophilic Esophagitis remains for esophagus involvement.<br />3. **Discarding “Eosinophilic Gastroenteritis”:** The term will no longer serve as an umbrella label due to its previous ambiguous use, and should only describe stomach and small bowel involvement.<br /><br />The consensus framework consists of two tiers:<br />- **First Tier:** Basic EGID terms for routine clinical use, focusing on specific locations within the GI tract.<br />- **Second Tier:** More detailed nomenclature for research, allowing precise clinical phenotyping, including specifics like exact segments of the bowel or multiple areas involved.<br /><br />**Delphi Process:**<br />- Conducted using two rounds of surveys completed by 91 experts from diverse medical fields and geographical regions.<br />- Achieved high response rates (93% for the first round and 90% for the second) indicating strong engagement and support from the experts.<br />- Ensured terminology was not ambiguous, preserved existing terms when clear, and incorporated granularity for research-use.<br /><br />**Challenges Addressed:**<br />- Variability in the use of terms like "eosinophilic gastroenteritis."<br />- Need for specific terminology for different small bowel segments.<br />- Importance of not unnecessarily complicating clinical assessments while capturing necessary detail for research.<br /><br />The new nomenclature aims to facilitate better clinical understanding, diagnosis, and treatment of EGIDs and to streamline research efforts, ensuring consistent terminology across studies. This framework is expected to evolve with emerging data to reflect the best practices and deeper scientific understanding.

Keywords

Eosinophilic gastrointestinal disease

EGID

Delphi methodology

Eosinophilic Gastritis

Eosinophilic Enteritis

Eosinophilic Colitis

Eosinophilic Esophagitis

Nomenclature consensus

Clinical phenotyping

GI tract inflammation