EoE ToT Module 3 References-Gupta M Canadian Digestive Health Foundation EOE-FAQs-english

Gupta M Canadian Digestive Health Foundation EOE-FAQs-english

Pdf Summary

Eosinophilic Esophagitis (EoE) is a chronic condition characterized by the inflammation of the esophagus. It affects individuals across all age groups, particularly those aged 5-14 years and 20-45 years. EoE commonly presents in children over 12 years of age with difficulty swallowing and chronic dysphagia (long-term trouble swallowing). Other symptoms include sensations of reflux, chest pressure, and painful swallowing when eating.<br /><br />The cause of EoE is believed to be an abnormal type 2 immune response to certain foods and possibly airborne allergens. Research continues to investigate the exact mechanisms behind the condition. There is currently no cure for EoE; however, consistent and regular therapy can significantly reduce the risk of narrowing and inflammation of the esophagus.<br /><br />Diagnosis of EoE requires a combination of clinical history and biopsy results from a gastroscopy, which should reveal high counts of eosinophils. It is important to consult a gastroenterologist to distinguish EoE from other conditions with similar biopsy findings, such as gastroesophageal reflux disease (GERD).<br /><br />Although EoE is a significant medical condition, current research finds no direct link between EoE and esophageal cancer. Reliable diagnosis and ongoing management are essential to handling EoE effectively and mitigating its symptoms.<br /><br />References:<br />1. Arias Á, Lucendo AJ. Epidemiology and risk factors for eosinophilic esophagitis: lessons for clinicians. Expert Review of Gastroenterology and Hepatology. 2020.<br />2. Straumann A, Bauer M, Fischer B, Blaser K, Simon HU. Idiopathic eosinophilic esophagitis is associated with a TH2-type allergic inflammatory response. J Allergy Clin Immunol.<br />3. Hirano I, Furuta GT. Approaches and Challenges to Management of Pediatric and Adult Patients With Eosinophilic Esophagitis. Gastroenterology. 2020.<br />4. Syed A, Maradey-Romero C, Fass R. The relationship between eosinophilic esophagitis and esophageal cancer. Dis Esoph. 2017; 30(7): 1-5.

Keywords

Eosinophilic Esophagitis

chronic inflammation

difficulty swallowing

dysphagia

immune response

gastroscopy biopsy

gastroenterologist

GERD

esophageal cancer

management