EoE ToT Module 3 References-Mohammad et al J Am Acad Dermatol 2017 Prevalence of atopic comorbidities in EoE A case control study of 449 patients

Mohammad et al J Am Acad Dermatol 2017 Prevalence of atopic comorbidities in EoE A case control study of 449 patients

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The research letter titled "Prevalence of atopic comorbidities in eosinophilic esophagitis: A case-control study of 449 patients" investigates the prevalence of atopic disorders in patients with eosinophilic esophagitis (EoE). EoE is a chronic immune-mediated esophageal disease characterized by symptoms of esophageal dysfunction and significant eosinophilic inflammation. The study was conducted using data from 449 patients who presented with clinical and pathological features of EoE at the Cleveland Clinic between January 2005 and June 2015.<br /><br />The study's findings indicate a strong association between EoE and atopic diseases such as asthma, allergic rhinitis, and atopic dermatitis. Specifically, 77.5% of the EoE patients had at least one atopic disease, while 47.9% had more than one, and 21.6% had all three. When compared to the general U.S. population, the prevalence rates in the EoE group were significantly higher: asthma (39.0% vs. 22.3%), allergic rhinitis (61.9% vs. 19.1%), and atopic dermatitis (46.1% vs. 8.3%).<br /><br />The study also found that patients with co-existing EoE and any atopic disease had significantly higher peripheral eosinophil counts and serum IgE levels, suggesting a potential systemic process in these patients. Additionally, those with atopic diseases were generally younger and more likely to have a family history of atopy.<br /><br />However, the study has limitations, including its retrospective design and reliance on chart reviews and self-reported data, which could lead to incomplete or overreported medical histories. Peripheral eosinophil counts and serum IgE levels were only available for a subset of patients, limiting the comprehensiveness of the comparisons.<br /><br />The findings highlight the need for physicians to consider the association between EoE and atopic disorders when treating patients with esophageal dysfunction.<br /><br />The study was conducted by Ahmad A. Mohammad, Sean Z. Wu, Omer Ibrahim, James Bena, Maged Rizk, Melissa Piliang, and Wilma F. Bergfeld, affiliated with St. George’s University School of Medicine, Case Western Reserve University School of Medicine, and the Cleveland Clinic Foundation. The research was published in the Journal of the American Academy of Dermatology in March 2017.

Keywords

eosinophilic esophagitis

atopic comorbidities

asthma

allergic rhinitis

atopic dermatitis

peripheral eosinophil counts

serum IgE levels

retrospective study

Cleveland Clinic

Journal of the American Academy of Dermatology