EoE ToT Module 4 References-Ram et al 2015 ABSTRACT Seasonal exacerbation of esophageal eosinophilia in children with EoE and allergic rhinitis

Ram et al 2015 ABSTRACT Seasonal exacerbation of esophageal eosinophilia in children with EoE and allergic rhinitis

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A study published in the "Annals of Allergy, Asthma & Immunology" investigates the seasonal exacerbation of esophageal eosinophilia in children diagnosed with eosinophilic esophagitis (EoE) and allergic rhinitis. The researchers, led by Gita Ram and colleagues, conducted a retrospective chart review of 1,180 pediatric patients with EoE to identify cases where seasonal aeroallergens might trigger flare-ups in the eosinophil count.<br /><br />The study was designed to determine the proportion of patients whose eosinophilic counts spiked due to seasonal environmental factors. Seasonal variation was defined as an increase to at least 15 eosinophils per high-power field, doubling the eosinophil count in consecutive seasonal biopsy specimens, without dietary or medication changes.<br /><br />Out of the 1,180 patients, 160 (14%) were suspected of having aeroallergen-associated triggers. Among these, 32 patients (20%) had biopsy-confirmed seasonal variations in eosinophil counts. Most of these 32 patients were boys (84%), had allergic rhinitis, and 75% had a history of asthma. Additionally, 22 of these 32 patients also had food-induced symptoms.<br /><br />The findings suggest that children with EoE and allergic rhinitis may experience seasonal exacerbations in their esophageal eosinophilia due to specific environmental aeroallergens. The study underscores the importance of identifying which environmental allergens these patients are sensitized to guide effective therapy.<br /><br />This report contributes valuable information to our understanding of the interaction between environmental factors and EoE in pediatric patients, highlighting the necessity of considering seasonal variations in the management and treatment of EoE.

Keywords

Eosinophilic Esophagitis

Allergic Rhinitis

Seasonal Exacerbation

Pediatric Patients

Aeroallergens

Eosinophil Count

Asthma

Environmental Factors

Biopsy

Retrospective Study