EoE ToT Module 4 References-Wen et al 2015 SUPPLEMENT NIHMS636701-supplement-supplement

Wen et al 2015 SUPPLEMENT NIHMS636701-supplement-supplement_1

Pdf Summary

The document presents data from a study on Eosinophilic Esophagitis (EoE) and Proton Pump Inhibitor-Responsive Esophageal Eosinophilia (PPI-REE). <br /><br />**Supplementary Table 1** lists subject distribution across various study sites: UCSD (36 subjects), UNC (31), Walter Reed (32), CCHMC (7), and Colorado (6). The subjects are categorized into five groups: Normal, EoE, Pre-PPI PPI-REE, Post-PPI PPI-REE, and GERD. The highest proportions of EoE and Pre-PPI PPI-REE subjects are at Walter Reed, while 100% of the CCHMC subjects have GERD. Colorado's subjects all fall into the Post-PPI PPI-REE category.<br /><br />**Supplementary Table 2** identifies a common set of 46 genes dysregulated in both EoE and PPI-REE. The table details the regulation, p-values, and fold changes for each gene. For instance, the gene UPK1B is up-regulated in both conditions, showing a fold change of 9.81 in EoE and 4.26 in PPI-REE. Other examples include TNFAIP6, highly up-regulated with a fold change of 156.18 in EoE and 31.96 in PPI-REE, and POSTN with notable up-regulation in both conditions (fold change of 297.61 in EoE and 116.17 in PPI-REE).<br /><br />**Supplemental Figures 1 and 2** provide visual data analyses:<br />1. **Figure 1** examines the influence of age (pediatric vs. adult) on the molecular severity of EoE and PPI-REE. Results suggest a significant disease factor difference (p = 0.02) but no significant age factor or interaction effects.<br />2. **Figure 2** looks into the effect of PPI treatment on the EoE transcriptome, particularly KCNJ2 expression. Analysis shows notable expression differences between EoE and normal conditions, but no significant impact from PPI treatment.<br /><br />These results contribute to understanding the molecular and clinical characteristics of EoE and PPI-REE, highlighting differences and similarities in gene dysregulation and treatment impacts.

Keywords

Eosinophilic Esophagitis

Proton Pump Inhibitor-Responsive Esophageal Eosinophilia

gene dysregulation

study sites

subject distribution

GERD

molecular severity

PPI treatment

KCNJ2 expression

clinical characteristics