Masterclass: Advanced GI Endoscopic Imaging (Live/Virtual) | December 2025-VIrtual Masterclass - Endoscopic Imaging - 03 - Endomicroscopy and Advanced Imaging in Barrett’s associated neoplasia

VIrtual Masterclass - Endoscopic Imaging - 03 - Endomicroscopy and Advanced Imaging in Barrett’s associated neoplasia - Wang

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Video Transcription

Video Summary

Dr. Ken Wang's lecture reviews the evolution and future of advanced imaging technologies for Barrett's esophagus. Early techniques like endocytoscopy and confocal laser endomicroscopy (CLE) enabled cellular-level visualization but were limited by small field views, technical challenges, and impracticality, leading to their decline in favor of enhanced white light endoscopy methods. Volume laser endomicroscopy (VLE), an OCT-based technology, allowed broader circumferential scans, identifying dysplasia and cancer invasion patterns non-invasively, though it faced commercial challenges. Emerging technologies such as angle resolved low coherence interferometry and spectroscopic OCT combine wide-field imaging with nanoscale subcellular analysis, aiming to detect molecular changes linked to cancer progression and chemotherapy resistance. Future imaging will integrate broad mucosal surveillance with detailed subcellular insights, enhancing early detection and personalized treatment of Barrett's esophagus beyond traditional histology-level methods.

Keywords

Barrett's esophagus

advanced imaging technologies

endocytoscopy

confocal laser endomicroscopy

volume laser endomicroscopy

spectroscopic OCT