Masterclass: Advanced GI Endoscopic Imaging (On-Demand) | December 2025-Detection of Squamous Cell Neoplasia of the Esophagus

Video Transcription

Video Summary

Dr. Robert Becerra from Queen’s University discussed squamous mucosa and neoplasia, emphasizing the importance of understanding normal squamous tissue before identifying abnormalities. He introduced the IPCL (intrapapillary capillary loops) classification, a critical tool in detecting squamous neoplasms using magnification and image-enhanced endoscopy such as NBI or BLI. The examination involves a systematic macroscopic evaluation using the Paris classification and Lugol’s iodine staining, where neoplastic areas show a distinctive “pink color sign.” Microscopic assessment focuses on changes in IPCL morphology, correlating vessel patterns with carcinoma depth and invasiveness. Dr. Becerra presented cases highlighting how comprehensive endoscopic assessment, combining macroscopic and microscopic examination, influences diagnosis, staging, and treatment decisions, underscoring the need for meticulous inspection and specialized techniques to optimize detection and therapeutic outcomes in esophageal squamous carcinoma.

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Robert Bechara

Keywords

squamous mucosa

neoplasia

IPCL classification

image-enhanced endoscopy

esophageal squamous carcinoma