Masterclass: Advanced GI Endoscopic Imaging (On-Demand) | December 2025-Real time Molecular Imaging in the GI tract

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Video Summary

The speaker highlights the urgent need for real-time molecular imaging in gastrointestinal (GI) endoscopy to improve diagnosis and targeted therapies, especially for cancers and inflammatory diseases. Molecular imaging identifies cellular abnormalities at a molecular level rather than relying solely on traditional histology, aiding early tumor detection and better treatment selection. Current approaches involve systemic or topical application of fluorescent probes such as peptides, aptamers, and lectins for rapid, specific binding. Fluorescent endoscopes and single-fiber multispectral probes enable visualization, while emerging label-free two-photon microscopy offers promise for future non-invasive imaging. The talk emphasizes that molecular imaging can refine patient care by guiding therapies like targeted antibodies and immunotherapy, improving outcomes and reducing unnecessary treatments. Despite challenges like probe delivery and regulatory hurdles, these technologies represent the next evolution in GI endoscopy, with potential to revolutionize detection, treatment, and monitoring of GI diseases based on molecular abnormalities rather than just visible lesions.

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Ken Wang

Keywords

molecular imaging

gastrointestinal endoscopy

fluorescent probes

targeted therapies

two-photon microscopy