Postgraduate Course at DDW: Complete Clinical Updates for Today's Practice | May 2025-ACUTE LIVER INJURY AND CHOLESTASIS IN THE INPATIENT SETTING

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Video Summary

Ashna Singh, a transplant hepatologist and gastroenterologist, delivered an interactive session on liver injury at Indiana University. Singh's presentation focused on distinguishing between acute liver injury, liver failure, and acute-on-chronic liver failure, supported by real inpatient cases. Attendees participated by discussing diagnostic criteria, common patterns, and culprits of liver injury, emphasizing the importance of clear criteria in identifying these conditions. Discussion topics included the clinical difference between liver injury and failure, where Singh highlighted that encephalopathy is a distinguishing feature present only in liver failure. Furthermore, Singh reviewed several patient cases, asking for audience input and explaining diagnostic and management strategies, such as calculating the R ratio to differentiate liver injury patterns. The session underscored the significance of a thorough history and systemic examination for accurate diagnosis. Singh also provided a guide on initial diagnostic steps based on liver chemistry patterns and highlighted tools like the use of liver biopsy in uncertain diagnoses. By sharing these insights, Singh aimed to enhance clinical decision-making capabilities in identifying and managing liver conditions.

Keywords

transplant hepatologist

gastroenterologist

liver injury

acute liver failure

diagnostic criteria

R ratio

liver biopsy

clinical decision-making