Postgraduate Course at DDW: Complete Clinical Updates for Today's Practice | May 2025-BO_Singh Acute Live Injury and Cholestasis in the Inpt Setting

BO_Singh Acute Live Injury and Cholestasis in the Inpt Setting

Pdf Summary

Dr. Ashina Singh's session at the Indiana University School of Medicine focuses on acute liver injury (ALI) and cholestasis in inpatient settings by examining real-world cases, promoting an interactive approach with open questions. The objectives include distinguishing between acute liver injury and acute liver failure, understanding liver injury patterns, and identifying common causes.<br /><br />Case studies showcase practical scenarios, such as Mohammed, a 40-year-old man experiencing liver issues possibly due to khat consumption, highlighting the importance of thorough patient histories and the role of herbal substances in liver damage. The case emphasizes the significance of resources like Livertox in identifying drug-induced liver injuries.<br /><br />In another case, Mike, a 54-year-old with a history of alcohol use, presents with elevated liver enzymes post-alcohol cessation, leading to an autoimmune hepatitis diagnosis. It illustrates the complexity of diagnosing liver diseases and the significance of recognizing diverse diagnostic criteria, including antibodies and biopsies.<br /><br />David's case, with complex symptoms including heart failure and infections, demonstrates non-hepatic factors affecting liver function, such as heart failure and thyroid disorders. This case reinforces the need to consider multi-organ interactions when diagnosing liver-related issues.<br /><br />Overall, Dr. Singh highlights the diagnostic process for elevated liver chemistries through comprehensive patient histories and evaluations detailed in recent literature. The session advises employing diagnostic algorithms to distinguish various etiologies such as viral infections, drug/toxin effects, ischemia, autoimmune conditions, genetic disorders, and others, ensuring thorough, evidence-based patient care in the inpatient setting.

Keywords

acute liver injury

cholestasis

inpatient settings

real-world cases

liver injury patterns

herbal substances

autoimmune hepatitis

multi-organ interactions

diagnostic algorithms

evidence-based care