The Best of ASGE Endoscopy from DDW | June 2021-Shamah_AbeAnnualMeeting2021

Shamah_AbeAnnualMeeting2021_Endozip

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This document discusses the topic of obesity and the potential use of plication techniques for weight reduction. Obesity is a global epidemic, with millions of people classified as obese or morbidly obese. Surgical interventions for obesity are underutilized, with only 15-20% of people in Israel receiving treatment. Endoscopic options are considered safer and intended for lower BMI patients, but they have limitations such as long learning curves and high skill requirements.<br /><br />The document introduces EndoZip, a semi-automated and minimally invasive suturing system designed for weight reduction in obese individuals. It is indicated for use in adults with a BMI of 30-40 kg/m2 who have failed weight reduction with diet and exercise alone. The EndoZip system aids in creating durable restrictive sutures.<br /><br />The first in-human study using the EndoZip prototype involved 11 patients with a BMI range of 30-40 kg/m2. The study showed positive weight loss outcomes, as well as reduced waist circumference. At 6 months, the mean total body weight loss (TBWL) was 17.8 kg, and the mean percentage TBWL was 16.2%. The mean percentage excess body weight loss (EBWL) was 54.3%.<br /><br />The features and benefits of the EndoZip system include operator independence, ease of use with a short learning curve, reproducible procedures, consistent suture size and depth, high suture density, and longer-lasting effects of restrictive sutures. These features aim to provide reproducible results in weight reduction.<br /><br />Currently, there is an ongoing international multi-center clinical trial to further evaluate the efficacy and safety of the EndoZip system.

Keywords

obesity

plication techniques

weight reduction

EndoZip

restrictive sutures

in-human study

total body weight loss

excess body weight loss

reproducible procedures

clinical trial