The Best of ASGE Endoscopy from DDW (On-Demand) | June 2021-Shamah_AbeAnnualMeeting2021

Shamah_AbeAnnualMeeting2021_Endozip

Pdf Summary

In this document, the author discusses the global epidemic of obesity and the need for effective treatments. They mention that surgical interventions for obesity are highly underutilized, with only 15-20% of patients in Israel receiving them. Endoscopic options are considered safer and more suitable for lower BMI patients. The author specifically references endoscopic gastroplasty as a long-lasting option with moderate weight loss results. However, they note that this procedure is cumbersome and requires high skill.<br /><br />The document introduces a new technique called EndoZip, which is a semi-automated, operator-independent, and minimally invasive suturing system. It is intended to aid in weight reduction for obese individuals with a BMI of 30-40kg/m2 who have failed to lose weight through diet and exercise alone. The EndoZip system allows for durable restrictive sutures to be placed in the gastric cavity to reduce weight.<br /><br />The document includes results from a first-in-human study using the first prototype of the EndoZip system. The study included 11 patients with a BMI range of 30-40kg/m2. The outcomes of the study showed significant weight loss and reduction in waist circumference after the EndoZip procedure. The mean total body weight loss (TBWL) at 6 months was 17.8 kg, with a mean percentage TBWL of 16.2% and mean percentage excess body weight loss (EBWL) of 54.3%.<br /><br />The author highlights the features and benefits of the EndoZip system, including operator independence, ease of use, reproducible procedures, consistent suture size and depth, and durable suturing. They also mention that an international multi-center clinical trial is currently underway to further evaluate the efficacy of the EndoZip system.<br /><br />Overall, the document discusses the global obesity epidemic, the limitations of current surgical interventions, and introduces the EndoZip system as a promising option for weight reduction in obese individuals. The results of the first-in-human study show significant weight loss, and the system is touted for its ease of use and reproducibility.

Keywords

global epidemic

obesity

surgical interventions

endoscopic options

EndoZip

weight reduction

BMI

first-in-human study

significant weight loss

operator independence