Video Tip: Refractory GERD | May 2023-Refractory GERD

Video Transcription

Video Summary

This video tip, sponsored by Braintree, a part of Cibela Pharmaceuticals, discusses refractory symptoms in patients despite proton pump inhibitor (PPI) therapy. There are three types of symptoms to consider: refractory reflux-like symptoms that may or may not be GERD-related, patients with prior GERD diagnosis and persisting symptoms (overlap syndromes), and refractory GERD with persisting objective evidence of GERD despite PPI therapy. The percentages of patients with persistent esophagitis despite PPI therapy vary based on the grade of esophagitis. The causes of PPI-refractory GERD include disrupted antireflux barrier, impaired esophageal clearance, inadequate acid suppression, certain conditions mimicking GERD, and other underlying esophageal disorders.

Keywords

refractory symptoms

proton pump inhibitor therapy

persistent esophagitis

PPI-refractory GERD

underlying esophageal disorders